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Uric Acid & Vitamin C: Devolution of Evolution in a 5G World

Uric Acid & Vitamin C: Devolution of Evolution in a 5G World

 

Introduction 

Uric acid is increasingly associated with metabolic diseases like insulin resistance, diabetes, hypertension, cardiovascular diseases, and even cancer.  Humans, unlike other animals, are unable to produce ascorbic acid, vitamin C.[1]   On top of that, humans have also lost the ability to degrade uric acid. [2]  It is believed that during evolution, increased uric acid as a result of genetic mutations, was instrumental in the survival of hominids as it offered not only antioxidant protection, but the ability to suppress insulin signaling, modulating insulin resistance and gluconeogenesis as adaptation to extended periods of food shortages during dramatic climate shifts.  In our world today, hyperuricemia, or excess serum uric acid can be the result of genetic polymorphisms, or diet modifications that rely on high levels of meat, seafood or even fat. The fact that hyperuricemia is often associated with various metabolic diseases and health disorders including gout, may be indications that it no longer serves the protective roles it once did millions of years ago.  In the attempt to recreate physiological responses that mirror our hominin hunter-gatherer ancestors, the reliance on low carbohydrate/zero carbohydrate, paleo, 100% carnivorous, or even ketogenic diets may encounter unexpected challenges from evolutionary adaptations that are contradictory in nature: that of insulin resistance and insulin sensitivity. This article will attempt to explain why uric acid was indispensable in the past; the roles uric acid play in insulin signaling, and how its limitations as an antioxidant and its inverse relationship with ascorbic acid are affected by our high technology world, ultimately changing the nature of its once protective features. 

 

Table of Contents

Introduction

Best Diet for Metabolic Syndrome

   Your Diet Is Predetermined By Your Genes?

        The GCKR Gene

        The TBC1D4 Gene

Carnivores & Insulin Resistance

   Genetic adaptations to Carnivory: GCKR & AGT

        AGT & Oxalates

Insulin Resistance, Gluconeogenesis & Uric Acid: The Surprise Trio

   Insulin Resistance as Metabolic Adaptation: Blessing or Curse?

        You Cannot Survive Without Glucose

        Gluconeogenesis in the Human Brain

   Gluconeogenesis & Type 2 Diabetes

   Insulin Inhibits Gluconeogenesis

Hyperuricemia & Metabolic Syndrome: Devolution of Evolution?

   Xanthine Oxidoreductase as Double-Edged Sword: NADH or Reactive Oxygen Species?

   Hyperuricemia Induces Insulin Resistance & Reduces Insulin Sensitivity

        Uric Acid: An Intracellular Source of Reactive Oxygen Species

   Uric Acid Homeostasis

        Underexcretion of Urate: A Story of Genetic Mutations

GULO and UOX: A Tale of Two Pseudogenes

   Neotropical Forests & The Loss of GULO

        Ascorbic Acid Synthesis Generates Hydrogen Peroxide

   Savannas & The Loss of UOX

Uric Acid in The Ice Ages

   Fructose, Obesity & Insulin Resistance: The Uric Acid Connection

        Uric Acid Stimulates Fat Accumulation: The Superoxide Connection

   Uric Acid Increases Gluconeogenesis by Suppression of AMPK & Insulin Signaling

        Uricase Blunts Gluconeogenesis, Restores AMPK Function

   Hyperuricemia & Hypertension: The Sodium Connection

        Insulin Resistance & The Ability to Hibernate

Ascorbic Acid & Uric Acid: The Yin & Yang of REDOX

   UV Radiation Protection: AA or UA?

   Birefringence

Redox Balancer versus Antioxidant-Prooxidant

Hyperuricemia & Cancer: The mTOR Connection

   Activation of mTOR by Uric Acid increases Stress Response

   Hyperuricemia Linked to Cancer

The Yin and Yang in Uric Acid

   UA & AA Protect Sperm Viability

Inverse Relationship between Ascorbic Acid and Uric Acid

   Ascorbic Acid Improves Insulin Sensitivity

Insulin Resistance & Insulin Sensitivity in a 5G World

   GLUT9 Polymorphisms Modulate Serum Uric Acid Levels

AA, UA & 5G – The REDOX Connection

   Uric Acid, Neurodegeneration & Cancer: The mTORC1 Connection

        Uric Acid Inhibits Nitric Oxide

        Nitric Oxide & Insulin Resistance

        Ascorbic Acid Regenerates BH4 to Produce Nitric Oxide

   Uric Acid & Cancer: The 8-oxoG Connection

       OGG1 Polymorphism & Insulin Resistance

Conclusion

REFERENCES:

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Doris Loh

Doris Loh

Doris Loh is an independent researcher and writer specializing in the investigation of familiar and innovative health topics using unique perspectives in traditional and quantum biology. Her training as a classical pianist allows her the freedom to explore concepts and theories with a curiosity that often results in distinctive conclusions. Recent works by Doris are focused on how health and disease are greatly affected by electromagnetic radiation that surround us everywhere we go. Her works on EMF offer insight and solutions to the challenges humans and other living organisms face during this era of change. Major works by Doris include an in-depth series on deuterium, as well as a startling series on the birefringent quantum properties of the major REDOX balancer, Vitamin C (ascorbic acid).

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