L’elenco di tutti i trial eseguiti sulla paleodieta, sia su umani (32) che su animali (5).
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L’elenco di tutti i trial eseguiti sulla paleodieta, sia su umani (32) che su animali (5).

di Angelo

tratto da un lavoro di Maelán Fontes Villalba e sviluppato ed aggiornato periodicamente da Angelo

(ndr. pensare che ho iniziato la paleodieta per bene nel 2002-2003… E c’era solo uno studio disponibile)

Iniziano ad essere tanti, anche se non hanno grandi campioni di riferimento, non hanno durate consistenti (tranne un paio)…
Hanno però un minimo comun denominatore: risultano sempre nettamente superiori alla dieta mediterranea o alle diete standard ufficiali:
un elenco asettico di tutti e 37 gli studi dedicati alla ‪‎dieta paleolitica‬.
Un paio di studi sono negativi ma solo nei commenti degli autori e non certo nella sostanza e sono commentati cliccando sui link.

Speriamo di aver fatto un servizio utile agli appassionati che desiderano approfondire l’argomento!

In ordine cronologico dal più vecchio al più recente:


Elenco trial eseguiti sulla paleodieta:

1. O’Dea K: Marked Improvement in carbohydrate and lipid metabolism in diabetic Australian aborigines after temporary reversion to traditional lifestyle. Diabetes 1984,

2. Jonsson T, Ahren B, Pacini G, Sundler F, Wierup N, Steen S, Sjoberg T, Ugander M, Frostegard J, Goransson Lindeberg S: A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. Nutr Metab (Lond) 2006, 3:39.

3. Lindeberg S, Jonsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjostrom K, Ahren B: A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia 2007, 50(9):1795-1807.

4. Osterdahl M, Kocturk T, Koochek A, Wandell PE: Effects of a short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr 2008, 62(5):682-685.

5.  Joaquín Pérez-Guisado et al. Spanish Ketogenic Mediterranean diet: a healthy cardiovascular diet for weight loss. Nutrition Journal 20087:30

6. Jönsson T, Granfeldt Y, Ahrén B, Branell UC, Pålsson G, Hansson A, Söderström M, Lindeberg S. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc Diabetol. 2009;8:35

7. Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Jr., Sebastian A: Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet.
Eur J Clin Nutr 2009.

8. Jonsson T, Granfeldt Y, Erlanson-Albertsson C, Ahren B, Lindeberg S. A Paleolithic diet is more satiating per calorie than a Mediterranean-like diet in individuals with ischemic heart disease. Nutr Metab (Lond). 2010 Nov 30;7(1):85

9. Carter P1, Achana F, Troughton J, Gray LJ, Khunti K, Davies MJ. A Mediterranean diet improves HbA1c but not fasting blood glucose compared to alternative dietary strategies: a network meta-analysis. J Hum Nutr Diet. 2014 Jun;27(3):280-97

10. Jönsson T, Granfeldt Y, Lindeberg S, Hallberg AC. Subjective satiety and other experiences of a Paleolithic diet compared to a diabetes diet in patients with type 2 diabetes. Nutr J. 2013 Jul 29;12:105. doi: 10.1186/1475-2891-12-105.

11. Ryberg M, Sandberg S, Mellberg C, Stegle O, Lindahl B, Larsson C, Hauksson J, Olsson T. A Palaeolithic-type diet causes strong tissue-specific effects on ectopic fat deposition in obese postmenopausal women. J Intern Med. 2013 Jul;274(1):67-76

12. Frassetto LA, Shi L, Schloetter M, Sebastian A, Remer T. Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic-Hunter-Gatherer-type diets. Eur J Clin Nutr. 2013 Sep;67(9):899-903

13. Fontes-Villalba M, Jönsson T, Granfeldt Y, Frassetto LA, Sundquist J, Sundquist K, Carrera-Bastos P, Fika-Hernándo M, Picazo Ó, Lindeberg S. A healthy diet with and without cereal grains and dairy products in patients with type 2 diabetes: study protocol for a random-order cross-over pilot study–Alimentation and Diabetes in Lanzarote–
ADILAN.Trials. 2014 Jan 2;15:2. doi: 10.1186/1745-6215-15-2.

14. Bisht B, Darling WG, Grossmann RE, Shivapour ET, Lutgendorf SK, Snetselaar LG, Hall MJ, Zimmerman MB, Wahls TL. A multimodal intervention for patients with secondary progressive multiple sclerosis: Feasibility and effect on fatigue. J Altern Complement Med. 2014 Jan 29. [Epub ahead of print]

15. Mellberg C, Sandberg S, Ryberg M, Eriksson M, Brage S, Larsson C, Olsson T, Lindahl B. Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial. Eur J Clin Nutr. 2014 Mar;68(3):350-7.

16. Smith, M, Trexler E, Sommer A, Starkoff B, Devor S.teven (2014) Unrestricted Paleolithic Diet is associated with unfavorable changes to blood lipids in healthy subjects. Int J Exer Sci 2014, 7(2) : 128-139.

17. Talreja D, Buchanan H, Talreja R, Heiby L, Thomas B, Wetmore J, Pourfarzib R, Winegar D. Impact of a Paleolithic diet on modifiable CV risk factors. Journal of Clinical Lipidology, Volume 8, Issue3, Page 341, May 2014.

18. Boers I, Muskiet FA, Berkelaar E, Schur E, Penders R, Hoenderdos K, Wichers HJ, Jong MC. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrom. A randomized controlled pilot-study. Lipids Health Dis. 2014 Oct 11;13:160. doi: 10.1186/1476-511X-13-160.

19. Stomby A, Simonyte K, Mellberg C, Ryberg M, Stimson RH, Larsson C, Lindahl B, Andrew R, Walker BR, Olsson T. Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women. Int J Obes (Lond). 2014 Oct 28. doi: 10.1038/ijo.2014.188. [Epub ahead of print]

20. Whalen KA, McCullough M, Flanders WD, Hartman TJ, Judd S, Bostick RM. Paleolithic and mediterranean diet pattern scores and risk of incident, sporadic colorectal adenomas. Am J Epidemiol. 2014 Dec 1;180(11):1088-97. doi: 10.1093/aje/kwu235. Epub 2014 Oct 17.

21. Bligh, H. F. J., Godsland, I. F., Frost, G., Hunter, K. J., Murray, P., MacAulay, K., et al. (2015). Plant-rich mixed meals based on Palaeolithic diet principles have a dramatic impact on incretin, peptide YY and satiety response, but show little effect on glucose and insulin homeostasis: an acute-effects randomised study. British Journal of Nutrition, 1–11.

22. Masharani, U., Sherchan, P., Schloetter, M., Stratford, S., Xiao, A., Sebastian, A., et al. (2015). Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. European Journal of Clinical Nutrition.

23. Pastore, R. L., Brooks, J. T., & Carbone, J. W. (2015). Paleolithic nutrition improves plasma lipid concentrations of hypercholesterolemic adults to a greater extent than traditional heart-healthy dietary recommendations. Nutrition Research (New York, N.Y.).


24. Otten J, Mellberg C, Ryberg M, Sandberg S, Kullberg J, Lindahl B, Larsson C, Hauksson J, Olsson T. Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention.
Int J Obes (Lond). 2016 Jan 20. doi: 10.1038/ijo.2016.4.

25. Blomquist C, et al. SUN-575. Presentato al: The Endocrine Society Annual Meeting; Aprile 1-4, 2016; Boston. qui

26. Maelán Fontes-Villalba, Staffan Lindeberg, Yvonne Granfeldt, Filip K. Knop, Ashfaque A. Memon, Pedro Carrera-Bastos, Óscar Picazo, Madhvi Chanrai, Jan Sunquist, Kristina Sundquist and Tommy Jönsson. Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial. Cardiovascular Diabetology 2016, 15:80 doi:10.1186/s12933-016-0398-1. Full Text

27. Genoni A, Lyons-Wall P, Lo J, Devine A. Cardiovascular, Metabolic Effects and Dietary Composition of Ad-Libitum Paleolithic vs. Australian Guide to Healthy Eating Diets: A 4-Week Randomised Trial. Nutrients. 2016 May 23;8(5). pii: E314.

28. Otten J, Stomby A, Waling M, Isaksson A, Tellström A, Lundin-Olsson L, Brage S, Ryberg M, Svensson M, Olsson T. Effects of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes. Diabetes Metab Res Rev. 2016 May 27. doi: 10.1002/dmrr.2828

29. Genoni A, Lo J, Lyons-Wall P, Devine A. Compliance, Palatability and Feasibility of PALEOLITHIC and Australian Guide to Healthy Eating Diets in Healthy Women: A 4-Week Dietary Intervention. Nutrients. 2016 Aug 6;8(8). pii: E481. doi: 10.3390/nu8080481.


30. Lee JE, et al. A Multimodal, Nonpharmacologic Intervention Improves Mood and Cognitive Function in People with Multiple Sclerosis. J Am Coll Nutr. 2017 Mar-Apr;36(3):150-168. doi: 10.1080/07315724.2016.1255160. Epub 2017 Apr 10

31. S Manousou et al. A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women. European Journal of Clinical Nutrition advance online publication 13 September 2017; doi: 10.1038/ejcn.2017.134

32. Blomquist C et al. Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet. Eur J Nutr. 2017 Oct 26. doi: 10.1007/s00394-017-1558-0

33. Stomby A et al. A Paleolithic Diet with and without Combined Aerobic and Resistance Exercise Increases Functional Brain Responses and Hippocampal Volume in Subjects with Type 2 Diabetes. Front Aging Neurosci. 2017 Dec 4;9:391. doi: 10.3389/fnagi.2017.00391.


34. Otten et al. A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial. Diabetologia. 2018 Apr 26. doi: 10.1007/s00125-018-4618-y.


35. Otten J et al. Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus. J Am Heart Assoc. 2019 Jan 22;8(2):e010634. doi: 10.1161/JAHA.118.010634.

36. Otten J. ed al. Postprandial levels of GLP-1, GIP, and glucagon after two years of weight loss with a Paleolithic diet: a randomized controlled trial in healthy obese women. Eur J Endocrinol. 2019 May 1. pii: EJE-19-0082.R1. doi: 10.1530/EJE-19-0082.

37. Genoni et Al. Long-term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations. Eur J Nutr. 2019 Jul 5. doi: 10.1007/s00394-019-02036-y

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Angelo 52 anni, ingegnere, papà di una bellissima figlia, ex ciclista e triatleta agonista con alcuni risultati apprezzabili. Dal 2004 ha sperimentato su se stesso la dieta paleo abbinata allo sport di endurance e seguito decine di altre esperienze analoghe su, forum tematici, di altri atleti ed appassionati come lui. Uno degli organizzatori dell'evento "paleomeeting", past president, attuale segretario e socio fondatore del SIMNE (Società Italiana di Medicina e Nutrizione Evoluzionistica). Co-autore de IL NUOVO VIVERE SECONDO NATURA ed autore del best seller INSONNIA. IL MALE DEL NUOVO SECOLO.

Palamita marinata by Angelo

Differenza di corsa con scarpe o scalzi: solo effetto “massa” o c’è altro?