THE LANCET LAUNCHES THE ATOMIC BOMB ON VITAMIN D ...
But you morons will continue to "integrate" precisely by virtue of the fact that you are full-blown morons.
What does serious science do when it wants to find out if a drug or supplement works? It performs very long-range RCTs on a large sample of double-blind subjects and monitors as an output the mortality from all causes that controls ON ALL (the famous benefit / risk ratio).
As I predicted 2 years ago in the book VITAMIN D, slowly all the long-term RCTs on this hormone are published and all return disappointing results in the short and even negative in the long-very long term.
THE LANCE it is considered (even by the VITAMIN D gurus) the most prestigious scientific journal ever and in these days it publishes a very large double-blind RCT on oral supplementation #VitaminD (60.000 IU / month) compared to placebo for 5 years shows no reduction of all-cause mortality among the elderly.
Vitamin D: 562 / 10.661 (5,3%)
Placebo: 538 / 10.649 (5.1%)
HR = 1,04 (95% CI 0,93-1,18, p = 0,47)
You will tell me that it is little, just corresponding to 2000 UI / Die ... And I answer as usual that:
a- 2000 IU / day is the maximum RDA allowed by law by the Ministry of Health;
B- but above all the subjects under VITAMIN D therapy saw their 25OHD3 (the only haematochemical parameter measured as usual) dramatically increase compared to the heterogeneous group which was given a "placebo".
In fact, the vitamin D group had a normal value of: 115 (SD 30) nmol / L (about 46 ng / mL) while the "placebo" group had a value of 77 nmol / L (about 30 ng / mL) a however optimal value for true science. But considered "deficient" by the vitamin D gurus and the various Methods.
For example, look at this recent graduate doctor who shoots random values without any reference, for this subject even 46 ng / mL would be a "deficient" "level".
Optimal because all and over 20.000 subjects involved in the study were HEALTHY ELDERLY and therefore not inflamed. It is the inflammation that causes the alleged "deficiency" of HORMONE D deposit, exactly 25OHD3. Inflammation which, if resolved at the root, causes the values to return to "bubble" on their own without HRT with Vitamin D.
Investigators took blood samples from 3943 randomly selected patients during follow-up to examine mean serum concentration of 25 (OH) D3
So there was a substantial physiological effect. THIS EFFECT simply did not translate from a CLINICAL point of view. OOPPPSSSSS !!!
Splendid use of a flexible parametric survival model with an interaction between the treatment arm and the elapsed time since randomization (using restricted cubic spline). Just to dispel any doubt or objection ...
This shows the NULL effect of vitamin D supplementation on all cause mortality over time.
Furthermore, history repeats exactly if we split the age of the participants (over 70 and under 70). Thus even further and possible "confounding effects" were canceled.
Incredible and incontrovertible statistical analyzes ...
Well here's what the authors concluded:
Administering vitamin D3 monthly to unscreened older people did not reduce all-cause mortality. Point estimates and exploratory analyzes excluding the early follow-up period were consistent with an increased risk of death from cancer. Pending further evidence, the precautionary principle would suggest that this dosing regimen might not be appropriate in people who are vitamin D-replete.
Monthly administration of vitamin D3 to unscreened elderly people did not reduce all-cause mortality. Point estimates and exploratory analyzes, excluding the initial follow-up period, were consistent with an increased risk of cancer death. Pending further evidence, the precautionary principle would suggest that this dosing regimen may not be appropriate in people who have normal levels of vitamin D.
that just the other day I proposed in this same blog this other work that already gives a very precise answer and confirms that if one is "deficient" he must go to solve the inflammatory problem at the root and not go to TOS like a moron like after all, he recommends his doctor (or guru) whom he trusts.
All confirmed and signed by this INCREDIBLE METANALYSIS OF OTHER SIMILAR RTCS IN JAMA.
Which concludes ...
In this updated meta-analysis, vitamin D supplementation was not associated with a reduction in major adverse cardiovascular events, single CVD endpoints (myocardial infarction, stroke, CVD mortality) or all cause mortality. The results suggest that vitamin D supplementation does not confer cardiovascular protection and is not indicated for this purpose.
Conclusion of the conclusions? GRAPPA MOUTHPIECE !!!!! BLACK SEAL !!!!!
BONUS: LEGEND WITH THE PARALLELISM OF SEMANTIC SCAMS
COVID-19 mRNA VACCINE: EXPERIMENTAL GENE DRUG
VITAMIN D: POWERFUL SECOSTEROID HORMONE
SUPPLEMENTATION WITH VITAMIN D: TOS (HORMONE REPLACEMENT THERAPY)
SUPPLEMENTATION VERY HIGH DOSAGE WITH VITAMIN D: TOS (HORMONAL REPLACEMENT THERAPY UNFORGETTABLE AND VERY DANGEROUS)
IMMUNIZATION FROM COVID-19 mRNA VACCINE: THE EXPERIMENTAL DRUG DOES NOT IMMUNIZE THE CEPPA
INFORMED CONSENT FOR THE COVID-19 VACCINE: I AM A HERO PARTICIPATING IN A MASS TRIAL WITH AT LEAST SOME SHORT-TERM STUDY DONE. IF I AM A CHILD, I ALSO GIVE ME THE CERTIFICATE OF COURAGE THAT MAY ALSO BE CARRIED OUT IN THE COFFIN AS AN INDELIBLE MEMORY.
COIMBRA / APOLLO METHOD: EXPERIMENTATION OF TREATMENTS NEVER STRICTLY TESTED ON HUMAN COMPLIANCES AND (DESPERATE) AND TOTALLY DEFICIENT HUMANS
COIMBRA / APOLLO DOCTOR: GRADUATE IN MEDICINE WHO BELIEVES TO BE GOD AND INSTEAD LIVES IN THE MAGICAL WORLD OF COGNITIVE DEFICITIES
AND SO ON ...
The show must go on ... And the guinea pigs are you ...
Good day everyone.