BIOHACKING, INSULIN AND KETONES

Written by Angelo

Categories: supplements | Healthcare

19 September 2023

Even in the most accredited scientific platforms there is more and more talk about biohacking [1].

“In the search for longevity and health, we must first defeat the chronic diseases of aging: cardiovascular diseases, hypertension, cancer, dementia, type 2 diabetes mellitus. These are hyperinsulinemia diseases that occur in different tissues.”

COMMENT: Obviously, hyperinsulinemia can be a cause (or contributing cause) due to excessive glycemic load, or a consequence of metabolic derailment due to redox imbalance, which is caused by multiple factors in addition to diet (lack of physical exercise, electromagnetic pollution, circadian dysregulation, disconnection with nature, etc.).

THE NEW LIVING ACCORDING TO NATURE

“Hyperinsulinemia reduces endogenous antioxidants, through increased consumption and decreased synthesis.”

COMMENT: The picture is much more complex than it seems: as explained above “The New Living According to Nature” and according to the reports we give in our courses, it is precisely the redox imbalance with the accumulation of reactive species (fundamental signaling molecules) that inhibits the entry of glucose into the cells, increasing insulin signaling to the point of resulting in insulin resistance and even beyond (from metabolic syndrome to diabetes). Consequently, the “antioxidant” molecules have to work hard to try to restore homeostasis, potentially going into depletion.

“Hyperinsulinemia drives glucose consumption, consuming 4 NAD+ to produce 2 acetyl groups; beta-oxidation, ketolysis and acetoacetate consume 2, 1 and 0, respectively. This reduces the ability to handle sirtuins, PARPs and oxidation, allowing reactive oxygen species to diffuse into the cytosol, increasing aerobic glycolysis, NF-kB and cell division signaling. Furthermore, by oxidizing cardiolipin, it reduces oxidative phosphorylation (OXPHOS) and the capacity for apoptosis, inducing a tumor phenotype. Over time, an increase in senescence/pathological cell population occurs, resulting in increased morbidity and mortality.”

COMMENT: Reactive oxygen species are fundamental for the emission of biophotons (all explained in “Electromagnetism: the basis of life”) with the consequent formation of biological water EZ, so we can triangulate the evidence by assuming that the so-called “oxidative stress ”, is nothing more than an attempt by the body to restore the structure of interfacial water. Furthermore, the presumed tumor dynamics is tainted by the lack of knowledge regarding the triggering factors, so it is good to keep in mind the difference between consequences and causes.
The fundamental question to ask is always: “Which came first, the chicken or the egg?”

ELECTROMAGNETISM: THE BASICS OF LIFE

“Beta-hydroxybutyrate (BHB), an antioxidant, metabolite and signaling molecule, increases the synthesis of antioxidants by preserving the availability of NAD+ and enhancing oxidative phosphorylation. Fasting and ketogenic diets increase ketogenesis, while reducing insulin secretion and requirements; hyperinsulinemia inhibits ketogenesis. Lifestyles that keep insulin levels low reduce the catabolism of antioxidants, also increasing their synthesis, improving the management of oxidative stress and mitochondrial function and, consequently, producing healthier cells. This promotes the health of tissues and organs which translates into an increase in healthy life expectancy, the first challenge to overcome in order to remain young until old age”.

COMMENT: Once again it is necessary to draw the usual conclusions and distinguish correlations from cause-effect relationships. From the latest evidence, ketones are very important molecules as they are anti-inflammatory and restore correct metabolism and the multiple mechanisms of cell signaling and hormonal regulation.
For this reason, ketogenic diets are very effective in counteracting the metabolic derailment induced by diets and lifestyles alien to our physiology. However, the real final objective is to restore metabolic flexibility, according to the principles widely described in "Mitochondrial Training", transforming ourselves into "machines" capable of using all energy substrates efficiently and according to the needs of the moment, without making us chronically dependent. by one in particular.
The theory of "oxidative stress" is largely flawed by enormous cognitive biases, as explained in "Electromagnetism: the basis of life", for which it is necessary to review the scientific literature from a different perspective, namely that of the "new biology", which revolves around to the biophysics of water and aromatic rings, plasmonic antennas peculiar to living organisms, capable of receiving and transmitting energy and information.

“Insulin is in a certain sense the nemesis of ketones, as it inhibits their production and therefore deprives us of their anti-aging properties…

Decreased insulin signaling has been shown to increase life expectancy and healthy life expectancy. Although, once again, insulin is essential for life, an excessive amount causes hyperinsulinemia, impairing the regulation of apoptosis. In contrast, insulin increases the cell cycle and replication rate, reducing inspection of DNA copying quality and intracellular maintenance processes. Insulin signals the cell to have an abundance of energy, increases growth and division, while decreasing repair.
Insulin (when in excess) can be considered an aging hormone, preventing the self-production of the powerful anti-aging ketone body BHB.”

COMMENT: Insulin is certainly linked to tissue "growth", while the presumed theory of the correct "copy" of DNA is somewhat controversial and speculative (the theory of mutations has undergone harsh and very pertinent criticism lately). The fundamental point lies precisely in the lack of ability to remove "unwanted" debris, which limits the body's detox capacity. Health is largely determined by the body's ability to get rid of toxins and various waste substances, so pathological processes largely start from this mechanism.
Toxin management is widely discussed by proponents of the “terrain theory,” such as Dr. Cowan, Kaufman, Bailey, and many others.
Hyperinsulinemia can be both the cause and the consequence of this mechanism (always in connection with the dynamics of the reactive species); among other things, these mechanisms are also expected as a consequence of emotional stress and have been widely discussed by Dr. Stefan Lanka, who has taken up the works of the famous Dr. Hamer.
In essence, it is necessary to give the body the possibility of self-healing and avoid making any condition chronic. In nature there are only short acute phases followed by rapid resolutions.

“Chronic insulin signaling is associated with an increased incidence of chronic diseases of aging. It has been shown that many of these conditions can be reduced through the production and use of ketone bodies.”

COMMENT: in light of what has been said, when tissues are not regenerated correctly and toxins accumulate, pathological mechanisms are established which induce continuous degeneration (senescence).
Coincidentally, BHB is an "anti-inflammatory" molecule, or rather a redox balancer [2], [3], unlike other simple "antioxidants" or "immunosuppressants" (such as high doses of vitamin D [4]).

IN CONCLUSION

Interventions such as intermittent fasting, the ketogenic diet (paleo and not with various surrogates) and supplementation with ketone bodies (esters and not those of raspberries or other amenities), can be valid tools for establishing anti-inflammatory processes and improving tissue metabolism , bringing the body back to a situation of homeostasis.
Obviously, it is always necessary to evaluate the context and avoid chronicity, favoring metabolic flexibility and mitochondrial health: how?

– Mitochondrial training
– Exposure to the sun and contact with Nature (Earthing)
– Photobiomodulation and phototherapy
– Circadian reset
– Redox balancers (such as “Redox Balance”)
– Stress and trauma management
– Protection from electromagnetic pollution and artificial lights
– Cold therapy
– Breathing techniques

REFERENCES

1) Cooper, ID; Kyriakidou, Y.; Petagine, L.; Edwards, K.; Elliott, BT Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximize Healthspan. Antioxidants 2023, 12, 1749. https://doi.org/10.3390/antiox12091749

2) Rojas-Morales, Pedro & Pedraza-Chaverri, José & Tapia, Edilia. (2019). Ketone bodies, stress response, and redox homeostasis. Redox Biology. 29. 101395. 10.1016/j.redox.2019.101395.

3) Youm, YH., Nguyen, K., Grant, R. et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nat Med 21, 263–269 (2015). https://doi.org/10.1038/nm.3804

4) Angelo Rossiello – Vitamin D

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