GAMMA WAVES AT 40Hz AND ALZHEIMER'S

Written by Angelo

Categories: Healthcare

February 29 2024

GAMMA WAVES AT 40Hz AND ALZHEIMER'S

The studies of MIT (Massachusetts Institute of Technology, we are practically talking about the greatest scientific minds in the world) but also other independent studies not carried out at MIT, are producing increasingly clear evidence that the "flickering" of light but also the "click" of sound Brain rhythm frequency range of 40 Hz can reduce the progression of Alzheimer's disease (AD) and treat symptoms in human volunteers and laboratory mice.

“Flicker” is improper, we must talk about PULSATION and in geometric terms. AN INSIGHT:

FLICKER EFFECT AND HEALTH MARKETING (PHOTOBIOMODULATION LAMPS)

This new study, among other things published on NATURE, reveals a key mechanism that may contribute to these beneficial effects:
the elimination of amyloid proteins, a hallmark of Alzheimer's pathology, through the brain's glymphatic system, a recently discovered "plumbing" network parallel to the brain's blood vessels.

“Since we published our first results in 2016, people have been asking me how does it work? Why 40 Hz? Why not another frequency?”

said senior study author Li-Huei Tsai, Picower professor of neuroscience and director of the Picower Institute and the Aging Brain Initiative at MIT.

“These are really very important questions that we have been working very hard on in the lab.”

The new paper describes a series of experiments, conducted by Mitch Murdock when he was a doctoral student in Cognitive and Brain Sciences at MIT, demonstrating that when sensory gamma stimulation increases power and synchrony at 40 Hz in the brains of mice, this induces the release of a particular peptide by neurons.

The study findings also suggest that those short protein signals then drive specific processes that promote greater clearance of amyloid through the glymphatic system.

DEPTH:

The Importance of Sleeping Well - The Glinfatico System.

“We don't yet have a linear map of the exact sequence of events that occur,” Murdock said, “But the results of our experiments support this clearance pathway through major glymphatic pathways.”

Because previous research has shown that the glymphatic system is a key conduit for clearing brain waste and can be regulated by brain rhythms, Tsai and Murdock's team hypothesized that it could help explain the lab's previous observations that stimulation Sensory gamma reduces amyloid levels in Alzheimer's model mice. .

Working with mice “5XFAD”, which genetically model Alzheimer's, Murdock and coauthors first replicated previous laboratory findings that 40 Hz sensory stimulation increases 40 Hz neuronal activity in the brain and reduces amyloid levels.

Then they began measuring whether there was any related change in the fluids flowing through the glymphatic system that facilitates waste disposal.

In fact, they measured increases in cerebrospinal fluid in the brain tissue of mice treated with sensory gamma stimulation compared to untreated controls. They also measured an increase in the rate of interstitial fluid leaving the brain.

Furthermore, in mice treated with 40Hz gamma frequencies, they showed increased diameter of the lymphatic vessels that drain fluid and increased accumulation of amyloid in the cervical lymph nodes, which is the site of drainage of that flow.

To study how this increase in fluid flow might occur, the team focused on the aquaporin 4 (AQP4) water channel of astrocyte cells, which allows the cells to facilitate glymphatic fluid exchange.

When they blocked APQ4 function with a chemical, this prevented sensory gamma stimulation from reducing amyloid levels and improving the mice's learning and memory. And when, as an additional test, they used a genetic technique to disrupt AQP4, it also interfered with amyloid clearance given gamma frequencies at 40Hz.

In addition to fluid exchange promoted by APQ4 activity in astrocytes, another mechanism by which gamma waves promote glymphatic flow is by increasing the pulsation of nearby blood vessels. Several measurements showed stronger arterial pulsatility in mice subjected to sensory gamma stimulation compared to untreated controls.

One of the best new techniques for monitoring how a condition, such as sensory gamma stimulation, affects different types of cells is to sequence their RNA to track changes in how they express their genes. Using this method, Tsai and Murdock's team saw that gamma sensory stimulation actually promoted changes consistent with increasing astrocytes' AQP4 activity.

The RNA sequencing data also revealed that after gamma sensory stimulation a subset of neurons, called “interneurons,” experienced a dramatic increase in the production of several peptides. This is not surprising in the sense that peptide release is known to depend on brain rhythm frequencies, but it is still noteworthy because one peptide in particular, VIP (Vasoactive intestinal peptide), is associated with benefits in fighting Alzheimer's and helps regulate vascular cells, blood flow and glymphatic clearance.

Taking advantage of this intriguing result, the team performed tests that revealed an increase in VIP in the brains of mice treated with 40Hz gamma frequencies. The researchers also used a peptide release sensor and observed that sensory gamma stimulation resulted in increased peptide release from VIP-expressing interneurons.

But did this 40Hz gamma frequency-stimulated peptide release mediate glymphatic clearance of amyloid?

To find out, the team performed another experiment: they chemically turned off the VIP neurons. When they did that, and then exposed the mice to sensory gamma stimulation, they found that there was no longer an increase in arterial pulsatility and there was no longer gamma-stimulated amyloid clearance.

“We think a lot of neuropeptides are involved”

Murdock said. Tsai added that an important new direction for the lab's research will be to determine what other peptides or other molecular factors might be driven by sensory gamma stimulation.

Tsai and Murdock added that although this paper focuses on what is likely an important mechanism – glymphatic clearance of amyloid – by which sensory gamma stimulation helps the brain, it is probably not the only underlying mechanism that matters. The clearance effects shown in this study occurred rather quickly, but in laboratory experiments and clinical studies, weeks to months of chronic sensory gamma stimulation were required to have sustained effects on cognition.

With each new study, however, scientists learn more about how sensory stimulation of brain rhythms can help treat neurological disorders.

https://www.nature.com/articles/s41586-024-07132-6

Some clarifications:

– the glymphatic system must unquestionably be stimulated by working on sleep and above all on the rebalancing of its natural ARCHITECTURE. If you sleep well, cleanse your brain NATURALLY by stimulating gamma waves yourself as has happened in Nature for millions of years.

FURTHER INFORMATION: INSOMNIA. THE EVIL OF THE NEW CENTURY

– this also explains why DAILY sunlight and without SUNGLASSES is crucial to prevent this terrible disease. Evidence from dozens and dozens of studies.

– this also paves the way for the use of our pulsed light technologies which not only stimulate gamma waves through the eyes, but are capable of working even to the heart of the brain with GAMMA WAVES. With a 650 EURO NEPTUNE!!!!

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