By Doris Loh
The SARS-CoV-2 virus has undergone many mutations since early 2020. Based upon current understanding of new variants that involve mutations in the nucleocapsid protein that can undergo liquid-liquid phase separation, the September 2021 Guidelines for melatonin dosage requires extensive revision. It is now crystal clear that both the timing and amount of melatonin used is critical in controlling viral replication and infection upon exposure. Inadequate amount and delayed application can extend symptom durations and potentially even result in the development of many long-term symptoms associated with LongCovid otherwise known as Post-Acute Sequelae of COVID-19 (PASC).
The April 2023 Revised Guidelines are derived from the Weight-Based (24 h) Dose (WBD) schedule. The WBD dose is allometrically scaled from proven effective animal doses under different parameters and infection status by various highly pathogenic viruses that also undergo phase separation [1]. The rationale for higher doses is based upon the concept that higher concentration is required to inhibit viral phase separation that supports replication and virulence [1,2]. Thus a higher MEL dose may mean reversing and controlling symptoms within 2 to 12 hours or days and weeks at inadequate doses.
For further understanding of how melatonin regulates phase separation of viruses, please read:
[1] Loh, D.; Reiter, RJ Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19. Int. J. Mol. Sci. 2022 , 23 (15), 8122. https://doi.org/10.3390/ijms23158122 .
The key to understanding why high doses may be necessary when using melatonin can be found in the ancient relationship between melatonin, ATP, and water. To learn more about this potent, effective ancient synergy, please read:
[2] Loh, D.; Reiter, RJ Light, Water, and Melatonin: The Synergistic Regulation of Phase Separation in Dementia. Int. J. Mol. Sci. 2023 , 24 , 5835. https://doi.org/10.3390/ijms24065835.
Please click the following links to read, print, and/or download the 2023 Melatonin Guidelines:
2023 April Melatonin Dosing Schedule (V2)
2023 April Melatonin PASC Guidelines (V2)
Have you had your MEL and AA today?
* Disclaimer: The statements in this article have not been evaluated by the Food and Drug Administration. Ascorbic acid, melatonin and any other product mentioned is not intended to diagnose, treat, cure or prevent any disease. The Guidelines are intended for information purposes only, and should not be considered as medical advice. When in doubt, please seek professional medical assistance.
